European journal of applied physiology
-
Eur. J. Appl. Physiol. · Mar 2016
Proof of concept: hypovolemic hyponatremia may precede and augment creatine kinase elevations during an ultramarathon.
It is not known if exercise-associated hyponatremia (EAH) is a cause or consequence of exertional rhabdomyolysis (ER).We hypothesized that osmotic stress (EAH) coupled with mechanical stress (running) potentiated muscle cell breakdown (ER). This concept would be supported if a nadir in serum sodium concentration ([Na(+)]) temporally preceded peak creatine kinase levels (CK) during an ultramarathon run. ⋯ Preliminary data support the possibility that transient hypovolemic EAH may precede and augment CK during an ultramarathon.