European journal of applied physiology
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Eur. J. Appl. Physiol. · Jul 2018
Right ventriculo-arterial uncoupling and impaired contractile reserve in obese patients with unexplained exercise intolerance.
Right ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV exercise responses, we investigated RV-arterial coupling in obesity with and without development of exercise pulmonary venous hypertension (ePVH). ⋯ Exercise RV-arterial uncoupling and reduced RV contractile reserve further characterise obesity-related exercise intolerance. RV dysfunction in obesity may develop independent of exercise LV filling pressures.