Research communications in chemical pathology and pharmacology
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Res. Commun. Chem. Pathol. Pharmacol. · Oct 1980
Effects of fluoxetine on electrically-induced spinal cord seizures in rats.
The effects of fluoxetine [an inhibitor of 5-hydroxytryptamine (5-HT) reuptake] on electrically-induced spinal cord seizures were determined by monitoring alterations in the total duration of seizure, as well as the durations of tonic flexion and extension. The capacity of fluoxetine to inhibit 5-HT reuptake in the spinal cord was confirmed by measurements of 5-hydroxyindoleacetic acid (5-HIAA) content. ⋯ However, a dose of 20 mg/kg did significantly reduce 5-HIAA content although it did not alter seizure activity. These results further support our earlier suggestion that 5-HT containing neurons in the spinal cord do not modulate electrically-induced seizures.
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Res. Commun. Chem. Pathol. Pharmacol. · Oct 1980
Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.
Nisoxetine and desipramine (inhibitors of norepinephrine reuptake) each exerted a suppressant effect on spinal cord seizures by decreasing the duration of tonic extension. In addition, desipramine increased the duration of tonic flexion and nisoxetine decreased the total duration of seizure. In contrast, citalopram (an inhibitor of 5-hydroxytryptamine reuptake) did not affect any of these seizure components. These observations support the concept that spinal cord noradrenergic, but not 5-hydroxytryptaminergic neurons act as attenuators of convulsive activity.