Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Aug 2000
Interaction of combined administration of intrathecal morphine with subcutaneous morphine or buprenorphine.
To analyze the mode of interaction of combined administration of intrathecal morphine with subcutaneous morphine or buprenorphine. ⋯ The combination of morphine ith with either morphine s.c. or buprenorphine s.c. resulted in a synergistic effect. This interaction might be due to the activation of the synergistic antinociceptive mechanisms between supraspinal and spinal levels.