Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · May 2002
Caspases promoted DADAG-induced apoptosis in human leukemia HL-60 cells.
To investigate the roles of caspases in diacetyldianhydrogalactitol (DADAG)-induced apoptosis in human leukemia HL-60 cells. ⋯ DADAG induced apoptosis in HL-60 cells by activating caspases. Caspases promoted apoptosis through the cleavage of substrates of PARP, lamin B, and DFF45.