Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Mar 2003
Comparative StudyAntisense candidates against protein kinase C-alpha designed based on phylogenesis and simulant structure of mRNA.
To optimize the antisense drug design by the combined method of phylogenetic analysis and secondary structure prediction and to get ideal candidates. ⋯ AP1261 may be of value as an antitumor agent or adjuvant and the combined method of phylogenetic analysis and secondary structure prediction is a potential helpful tool for antisense drug design.