Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Oct 2004
Effects of ulinastatin on renal ischemia-reperfusion injury in rats.
To investigate the effect and possible mechanism of ulinastatin on renal ischemia-reperfusion injury in rats. ⋯ The protease inhibitor, ulinastatin, reduced the renal dysfunction and injury associated with ischemia-reperfusion of the kidney. The protective effect of ulinastatin might be associated with the up-regulation of Bcl-2 expression and the effect on membrane fragility.