Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Mar 2004
Randomized Controlled Trial Clinical TrialAntioxidative effect of propofol during cardiopulmonary bypass in adults.
To investigate the antioxidative potential of propofol (an intravenous anesthetic with a chemical structure similar to phenol-based free radical scavengers such as vitamin E) during cardiopulmonary bypass (CPB). ⋯ Cardio-pulmonary bypass is associated with a great production of damaging free radicals. Propofol may be beneficial both as an anesthetic and as a potent free radical scavenger in patients presenting pathologies associated with free radical reactions during CPB.