Acta pharmacologica Sinica

The most recent articles from: Acta Pharmacol. Sin. August 2004

Acta Pharmacol. Sin. · Aug 2004

Polymorphism of Prodynorphin promoter is associated with schizophrenia in Chinese population.

To investigate the correlation between single nucleotide polymorphisms (SNPs) of functional candidate gene Prodynorphin (PDYN) and schizophrenia. ⋯ PDYN-946C>G polymorphism demonstrated an association with population susceptibility to schizophrenia.

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Acta Pharmacol. Sin. · Aug 2004

Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats.

To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats. ⋯ Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development.

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