Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · May 2006
Influence of age and sex on pharmacodynamics of propofol in neurosurgical patients: model development.
To determine propofol concentration in the cerebral spinal fluid (CSF) of neurosurgical patients and carry out a preliminary population pharmacodynamic study. ⋯ Linear additive, linear exponential and sigmoid E(max) models can be used to describe the pharmacodynamics of propofol with respect to the concentration in CSF. In this small population, age (17-74 years), weight (47-98 kg) and sex did not influence any of the pharmacodynamic parameters of propofol. To verify these preliminary results, a larger study population is required.