Acta pharmacologica Sinica
-
Acta Pharmacol. Sin. · Jun 2007
Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent.
To investigate the mechanism of silibinin-protected isoproterenol-induced apoptosis in rat cardiac myocytes. ⋯ Silibinin is suggested to protect isoproterenol-induced rat cardiac myocyte apoptosis by activating the tyrosine kinase pathway, PKC and MAPK pathways.