Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Mar 2008
Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors.
To characterize the functional and pharmacological features of agonist-induced hump currents in human alpha4beta2-nicotinic acetylcholine receptors (nAChR). ⋯ These results support the hypothesis that hump currents reflect a rapid release of agonists from the alpha4beta2-nAChR channel pore and a rapid recovery from desensitized alpha4beta2-nAChR.