Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Oct 2010
Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1.
To examine the contribution of vascular membrane-associated prostaglandin E2 synthase-1 (mPGES-1) to acute blood pressure homeostasis. ⋯ Vascular mPGES-1 acts as an important tonic vasodilator, contributing to acute blood pressure regulation.