Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · May 2010
Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis.
To investigate the effect of systemic administration dexmedetomidine, a selective alpha 2 adrenergic receptor (alpha(2)AR) agonist, on thermal hyperalgesia and spinal glial activation evoked by monoarthritis (MA). ⋯ Systemic dexmedetomidine inhibits the activation of spinal glia, which is possibly associated with its antihyperalgesia in monoarthritic rats.
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Acta Pharmacol. Sin. · May 2010
GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells.
To explore the role of activation of glucagon-like peptide 1 receptor (GLP-1R) and its relative cell signaling pathway in the cytoprotection of geniposide. ⋯ GLP-1R plays a critical role in geniposide-induced HO-1 expression to attenuate oxidative insults in PC12 cells.