Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · Mar 2013
Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats.
To investigate the long-term effects of alendronate (Aln), a widely used oral bisphosphonate, on fracture healing and bone remodeling in ovariectomized rats. ⋯ In the ovariectomized rat model, Aln is beneficial for the mechanical properties of the callus, but delays callus remodeling by suppressing the remodeling of woven bone into lamellar bone.