Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · May 2015
Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage.
The proteolytic cleavage of Tau is involved in Aβ-induced neuronal dysfunction and cell death. In this study, we investigated whether atorvastatin could prevent Tau cleavage and hence prevent Aβ1-42 oligomer (AβO)-induced neurotoxicity in cultured cortical neurons. ⋯ Atorvastatin prevents AβO-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting calpain- and caspase-mediated Tau cleavage.
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Acta Pharmacol. Sin. · May 2015
Novel κ-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation.
To characterize the pharmacological profiles of a novel κ-opioid receptor agonist MB-1C-OH. ⋯ MB-1C-OH is a novel κ-opioid receptor agonist that produces potent antinociception causing less sedation and depression.