Acta pharmacologica Sinica
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Acta Pharmacol. Sin. · May 2002
Caspases promoted DADAG-induced apoptosis in human leukemia HL-60 cells.
To investigate the roles of caspases in diacetyldianhydrogalactitol (DADAG)-induced apoptosis in human leukemia HL-60 cells. ⋯ DADAG induced apoptosis in HL-60 cells by activating caspases. Caspases promoted apoptosis through the cleavage of substrates of PARP, lamin B, and DFF45.
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Acta Pharmacol. Sin. · Feb 2002
Comparative StudyComparison of norepinephrine-dobutamine to dopamine alone for splanchnic perfusion in sheep with septic shock.
To compare the effect of norepinephrine-dobutamine with dopamine alone on splanchnic perfusion in sheep with septic shock. ⋯ Both norepinephrine-dobutamine and dopamine alone could improve systemic hemodynamics in sheep with septic shock, but norepinephrine-dobutamine was better than dopamine on splanchnic perfusion.
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To study the analgesic effect of endomorphin-1 (EM-1). ⋯ EM-1 had a definite analgesic effect and the analgesic effect of EM-1 was mediated by central mu-opioid receptor.
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Acta Pharmacol. Sin. · Oct 2001
Effects of methylprednisolone and aprotinin on phospholipase D activity of leukocytes in systemic inflammatory response induced by cardiopulmonary bypass.
To investigate the role of leukocyte phospholipase D (PLD) in systemic inflammatory response induced by cardiopulmonary bypass (CPB) and the effects of methylprednisolone and aprotinin on leukocyte PLD activity. ⋯ Leukocyte PLD activity was elevated significantly in systemic inflammatory response induced by CPB and methylprednisolone partially blunted the CPB-induced inflammatory response by inhibiting PLD activity.
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Acta Pharmacol. Sin. · May 2001
Protective effect of nimodipine against cerebral injury induced by subacute carbon monoxide intoxication in mice.
To study the effects of nimodipine on delayed cerebral injury in mice from subacute carbon monoxide (CO) exposure. ⋯ Pretreatment with nimodipine markedly prevented mice from delayed encephalopathy after CO poisoning.