Veterinary anaesthesia and analgesia
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Randomized Controlled Trial
Cardiovascular effects following epidural injection of romifidine in isoflurane-anaesthetized dogs.
To investigate the cardiovascular effects of epidural romifidine in isoflurane-anaesthetized dogs. ⋯ Similar cardiovascular monitoring is required after epidural and systemically administered romifidine. Further studies are required to evaluate the analgesic effects of epidural romifidine.
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Randomized Controlled Trial
Pharmacokinetics of intra-articular morphine in horses with lipopolysaccharide-induced synovitis.
To describe the pharmacokinetics of intra-articularly (IA) administered morphine. ⋯ Intra-articularly administered morphine remained within the joint for at least 24 hours. At the same time only very low serum concentrations of morphine and M6G were detected. The present results suggest that IA morphine at 0.05 mg kg(-1) may be used for IA analgesia lasting at least 24 hours and give strong support to the theory that previously observed analgesic and anti-inflammatory effects of IA morphine in horses are most likely to be mediated peripherally.
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Randomized Controlled Trial
Cardiopulmonary and isoflurane-sparing effects of epidural or intravenous infusion of dexmedetomidine in cats undergoing surgery with epidural lidocaine.
To compare the cardiorespiratory, anesthetic-sparing effects and quality of anesthetic recovery after epidural and constant rate intravenous (IV) infusion of dexmedetomidine (DEX) in cats given a low dose of epidural lidocaine under propofol-isoflurane anesthesia and submitted to elective ovariohysterectomy. ⋯ Epidural and CRI of DEX significantly decreased isoflurane consumption and resulted in recovery of better quality and longer duration, despite bradycardia, without changes in systemic blood pressure.
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Randomized Controlled Trial
Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses.
To compare the analgesic effect of intra-articular (IA) and intravenous (IV) morphine in horses with experimentally induced synovitis. ⋯ An analgesic effect of IA morphine was demonstrated by significantly reduced lameness scores. The results support the common practice of including IA morphine in a multimodal analgesic protocol after arthroscopic surgery, although further studies in clinical cases are needed. The employed CMPS had good reproducibility, and was easy to use, but may have limited sensitivity at mild intensity pain.