Veterinary anaesthesia and analgesia
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Randomized Controlled Trial
Prevention of laryngospasm with rocuronium in cats: a dose-finding study.
To identify the dose of rocuronium that will prevent a laryngeal response to water spraying of the glottis in anesthetized cats. ⋯ Rocuronium 0.3 mg kg(-1) and 0.6 mg kg(-1) consistently decreased the completeness and duration of the laryngeal response to water spray, and reduced the number of arytenoid adductive movements in response to that stimulus. However, a laryngeal response was never completely prevented. Rocuronium 0.3 mg kg(-1) may be useful for facilitating tracheal intubation. Positive pressure ventilation must be available for cats administered rocuronium.
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Does inflammation induced by ultraviolet B and heat rekindling alter pain-related behaviour in rats?
To investigate whether induction of the ultraviolet B and heat rekindling (UVB/HR) model alters burrowing behaviour in rats. ⋯ Pain associated with UVB/HR model induction is below the threshold required to affect rat burrowing behaviour and therefore questions the face validity of UVB/HR as a translational model of inflammatory pain.
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To describe an ultrasound-guided approach for lumbar plexus catheter placement in dogs. ⋯ This technique has shown a high percentage of success and low rate of complications. The only complication investigated in this study was the spread to the abdomen or epidural space. To establish safety, clinical studies will be needed.
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To assess the effect of two rates of infusion of dexmedetomidine on the bispectral index (BIS) in dogs anaesthetized with alfaxalone constant rate infusion (CRI). ⋯ Administration of dexmedetomidine (2 μg kg(-1) + CRI 1 μg kg(-1) hour(-1) ) decreases the BIS values and avoids the autonomic responses of a nociceptive stimulus during alfaxalone anaesthesia at 0.07 mg kg(-1) minute(-1) in dogs. However, further studies are needed to verify whether this combination produces an adequate degree of hypnosis under surgical situations.
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Randomized Controlled Trial Comparative Study
Comparison of bupivacaine and dexmedetomidine femoral and sciatic nerve blocks with bupivacaine and buprenorphine epidural injection for stifle arthroplasty in dogs.
To compare the quality of anesthesia and analgesia from femoral and sciatic nerve blocks (FS) with bupivacaine and dexmedetomidine with that from an epidural injection (EPI) with bupivacaine and buprenorphine in dogs undergoing unilateral stifle arthroplasty. ⋯ Both techniques have the potential to provide sufficient analgesia for up to 24 hours in approximately two-thirds of dogs. Careful observation for signs of pain and preparedness to intervene is still recommended. The incidence of urinary retention was low in both groups. These techniques show promise for providing high-quality analgesia for stifle arthroplasty.