Veterinary anaesthesia and analgesia
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To compare the duration of action of vecuronium in diabetic dogs with a control group. ⋯ The duration of action of vecuronium was shorter in diabetic dogs as indicated by both tactile and EMG monitoring.
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To evaluate the endotracheal tube cuff pressure achieved by four different inflation methods. ⋯ None of the methods evaluated in this study can be considered effective for inflating the endotracheal tube cuff to within the optimal range when using silicone tubes. Direct measurement of the cuff pressure with a manometer is therefore recommended.
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To evaluate the potency and duration of three subparalyzing doses of vecuronium (VEC) in isoflurane-anesthetized horses. ⋯ A dose of 100 μg kg(-1) VEC in isoflurane anesthetized horses failed to produce complete paralysis. The partial neuromuscular block lasted at least 2 hours after this dose had been administered. Edrophonium was required to reverse the neuromuscular block in three of four horses. It is likely that more than 100 μg kg(-1) VEC would be necessary for complete neuromuscular blockade in horses, and that this dose will last >2 hours.