Veterinary anaesthesia and analgesia
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To compare the effect of intraperitoneal (IP) or incisional (INC) bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. ⋯ Intraperitoneal bupivacaine resulted in lower pain scores during the first hour of the postoperative period and there was a trend towards a decreased need for rescue analgesia after OHE in dogs.
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Randomized Controlled Trial
Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs.
To compare the anaesthetic and cardiopulmonary effects of alfaxalone with propofol when used for total intravenous anaesthesia (TIVA) during ovariohysterectomy in dogs. ⋯ Following premedication with acepromazine and morphine, both propofol and alphaxalone produce good quality anaesthesia adequate for ovariohysterectomy. Hypoventilation occurs suggesting a need for ventilatory support during prolonged infusion periods with either anaesthetic agent.
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Randomized Controlled Trial
Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs.
To compare the incidence of pain during injection of three intravenous induction agents in dogs. ⋯ No dogs reacted to saline or Drug(A,) thus Drug(A) was excluded from analysis. Pain on injection occurred in six dogs (20%) with Drug(PC) and one dog (3.3%) with Drug(P). Pain was severe in four dogs with Drug(PC). Drug(P) resulted in a trend for reduced risk of pain compared to Drug(PC) (p = 0.076, odds ratio [confidence intervals] 0.14 [0.027-0.86]). Both propofol formulations resulted in greater risk of excitation than Drug(A) (p = 0.0003, odds ratio 4.5 [1.86-10.90]). Induction agent was associated with pain, whilst catheter placement was not. One dog developed facial oedema and one other dog skin necrosis adjacent to the catheter site following Drug(PC.) The study was terminated early due to ethical concerns about the severity of reactions with Drug(PC). conclusions and clinical relevance: Drug(PC) was associated with clinically relevant moderate to severe pain behaviour whilst Drug(A) and Drug(P) were not.
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To investigate the changes in serum enzymes considered as biochemical indicators of hepatobiliary function in dogs following 5 hours of anaesthesia with isoflurane (ISO) or sevoflurane (SEVO). ⋯ Both ISO and SEVO, at concentrations used for clinical anaesthesia, produce transient moderate effects on some hepatobiliary enzyme concentrations in dogs.