Veterinary anaesthesia and analgesia
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Randomized Controlled Trial
Pharmacokinetics of hydromorphone hydrochloride in healthy dogs.
To assess the pharmacokinetics of hydromorphone administered intravenously (IV) or subcutaneously (SC) to dogs. ⋯ Hydromorphone has a short half-life, suggesting that frequent dosing intervals are needed. Based on pharmacokinetic parameters calculated in this study, 0.1 mg kg(-1) IV or SC q 2 hours or a constant rate infusion of hydromorphone at 0.03 mg kg(-1) hour(-1) are suggested for future studies to assess the analgesic effect of hydromorphone.
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Comparative Study Controlled Clinical Trial
Comparison between acceleromyography and visual assessment of train-of-four for monitoring neuromuscular blockade in horses undergoing surgery.
To compare acceleromyography (AMG) with visual assessment of train-of-four (TOF) for monitoring neuromuscular blockade and detecting residual muscle paralysis in horses receiving atracurium. ⋯ There was no substantial advantage for AMG in detecting the onset of atracurium-induced neuromuscular blockade. However, AMG detected residual blockade when visual assessment of TOF did not. Application of AMG is likely to reduce the incidence of residual blockade.
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To establish the correlation between the bispectral index (BIS) and different rates of infusion of propofol in dogs. Study design Prospective experimental trial. ⋯ An increase in propofol infusion rates decreases the BIS values and EMG.
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Randomized Controlled Trial
A comparison of ketamine-midazolam and ketamine-medetomidine combinations for induction of anaesthesia in rabbits.
To compare ketamine-midazolam (KMZ) and ketamine-medetomidine (KMT) anaesthesia in rabbits using anaesthetic induction, maintenance and recovery data. ⋯ KMT has a faster onset of action and a greater isoflurane-sparing effect when compared with KMZ. Rabbits with KMT were more prone to laryngospasm and had significantly lower HR.
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Randomized Controlled Trial
Thiopental and halothane dose-sparing effects of magnesium sulphate in dogs.
To evaluate the effect of pre- and intraoperatively administered magnesium sulphate (MgSO(4)) on the induction dose of thiopental and of halothane for maintenance of anaesthesia in dogs undergoing ovariohysterectomy (OHE). ⋯ Magnesium sulphate administration reduced the induction dose of thiopental and ET(hal) concentration for maintenance of anaesthesia in dogs undergoing OHE. Observed side effects were nausea and vomiting.