The lancet oncology
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The lancet oncology · Sep 2017
Meta AnalysisRole of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials. ⋯ Institut National du Cancer; and Ligue Nationale Contre le Cancer.