The lancet oncology
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The lancet oncology · Mar 2021
Meta AnalysisIntermediate clinical endpoints for surrogacy in localised prostate cancer: an aggregate meta-analysis.
The international Intermediate Clinical Endpoints in Cancer of the Prostate working group has established metastasis-free survival as a surrogate for overall survival in localised prostate cancer based on the findings of 19 predominantly radiotherapy-based trials. We sought to comprehensively assess aggregate trial-level performance of commonly reported intermediate clinical endpoints across all randomised trials in localised prostate cancer. ⋯ Prostate Cancer Foundation and National Institutes of Health.