Archives of oral biology
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Archives of oral biology · Jun 2014
Hypoxia-inducible factor-1α is required for transforming growth factor-β1-induced type I collagen, periostin and α-smooth muscle actin expression in human periodontal ligament cells.
We reported previously that hypoxia inducible factor (HIF)-1α was not degraded under normoxic condition with transforming growth factor (TGF)-β1 stimulation in human periodontal ligament (PDL) cells; however, the role of HIF-1α has been unclear. Recently, HIF-1α, working together with TGF-β1, has been reported to promote extracellular matrix accumulation under normoxic condition in renal epithelial cell. The aim of this study is to investigate the effects of HIF-1α on the expression of TGF-β1-mediated genes including type I collagen, periostin and α-smooth muscle actin (SMA) in human PDL cells. ⋯ HIF-1α is required for TGF-β1-induced type I collagen, periostin and α-SMA expression in human PDL cells.