Archives of oral biology
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Archives of oral biology · Mar 2015
Lithium inhibits palatal fusion and osteogenic differentiation in palatal shelves in vitro.
Glycogen synthase kinase-3β (Gsk-3β)/β-catenin signaling regulates development of the secondary palate. It has been unclear about the effects of Gsk-3β/β-catenin signaling on palatal fusion and osteogenic differentiation in palatal shelves. ⋯ Our findings show that LiCl-mediated GSK3β inhibition prevents palatal fusion and osteogenic differentiation in palatal shelves by increased β-catenin signaling. It indicated that overactivation of canonical Wnt signaling might impair the fusion of the secondary palate.