Archives of oral biology
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Archives of oral biology · Aug 2012
ReviewConcomitant consumption of marijuana, alcohol and tobacco in oral squamous cell carcinoma development and progression: recent advances and challenges.
Oral squamous cell carcinoma (OSCC) corresponds to 95% of all malignant tumours of the mouth. The association between alcohol and tobacco is the major risk factor for this disease, increasing the chances for the development of OSCC by 35-fold. The plant, Cannabis sativa is smoked as cigarettes or blunts and is commonly used in association with tobacco and alcohol. ⋯ However, Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the major psychotropic cannabinoid found in plants, causes a reduction of cellular metabolism and induction of apoptosis, both of which are anti-neoplastic properties. Apart from limited epidemiologic and experimental data, the effects of concomitant chronic exposure to marijuana (or Δ(9)-THC), tobacco and alcohol in OSCC development and progression is poorly known. This paper reviews the most recent findings on the effects of marijuana over cellular proliferation, as well as in the risk for OSCC, with emphasis on its interaction with tobacco and ethanol consumption.
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Archives of oral biology · Nov 2011
ReviewGenomics and the new perspectives for temporomandibular disorders.
The field of temporomandibular disorders (TMD) is experiencing significant changes in terms of aetiology and treatment. Researchers and clinicians are becoming increasingly aware of the possibility that genetic variations may play a role in pain perception and onset of TMD. ⋯ The main implication of these findings refers to the promising possibilities of "genome/omics-based personalised care", which consists of tailoring individual treatment based on personalised medication, depending on the individual genetic differences and early diagnosis and prognosis of the disorder, preventing acute pain conditions from becoming chronic. The following years of research shall focus on collecting and endorsing these findings if we are to provide patients in pain with efficient and successful TMD treatments.
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Archives of oral biology · Apr 2007
ReviewPostnatal changes of local neuronal circuits involved in activation of jaw-closing muscles.
Feeding behaviour in mammals changes from suckling to mastication during postnatal development and the neuronal circuits controlling feeding behaviour should change in parallel to the development of orofacial structures. In this review we discuss the location of excitatory premotor neurons for jaw-closing motoneurons (JCMNs) and postnatal changes of excitatory synaptic transmission from the supratrigeminal region (SupV) to JCMNs. ⋯ We also show that the incidence of post-spike afterdepolarization increases during postnatal development, whereas the amplitude and half-duration of the medium-duration afterhyperpolarization decrease with age. Such postnatal changes in synaptic transmission from SupV to JCMNs and membrane properties of JCMNs might be involved in the transition from suckling to mastication.
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Archives of oral biology · Sep 2006
ReviewMasticatory muscle pain and disordered jaw motor behaviour: Literature review over the past decade.
The clinically important relationship between masticatory muscle pain (MMP) and disordered jaw motor behaviour is subject of this concise, evidence-based review of the literature that was published during the past 10 years. Mainly based on studies that used some sort of experimental MMP (e.g., the intramuscular injection of noxious substances like hypertonic saline), it was concluded that MMP has pronounced effects on jaw motor functions like maximal clenching and mastication. ⋯ Further, MMP was shown to influence the cervical motor system, which may partly explain the mechanism behind the frequently observed co-occurrence of pain in the neck and the jaw. Finally, it was concluded that, even though the evidence is not yet conclusive, also remote pain (non-MMP) can modulate jaw motor behaviour, which indicates the involvement of central mechanisms in this modulation.