Laboratory animal science
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Laboratory animal science · Aug 1995
Acute Mycoplasma pulmonis infection associated with coagulopathy in C3H/HeN mice.
Experimentally induced infection with high doses of Mycoplasma pulmonis results in acute pneumonia characterized by severe pulmonary hemorrhage, edema, and, often, death in C3H/HeN mice. To determine whether specific disease manifestations were associated with coagulopathy, we measured serum fibrin, fibrinogen degradation products, and plasma fibrinogen concentrations in C3H/HeN mice infected with high doses of a virulent strain of M. pulmonis. ⋯ Rather than decreasing, as might be expected during a consumptive coagulopathy, fibrinogen concentrations increased. The hyperfibrinogenemia probably is associated with an acute phase response to M. pulmonis infection.