Emergency medicine journal : EMJ
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema.
Continuous positive airways pressure (CPAP) and bilevel non-invasive ventilation may have beneficial effects in the treatment of patients with acute cardiogenic pulmonary oedema. The efficacy of both treatments was assessed in the UK emergency department setting, in a randomised comparison with standard oxygen therapy. ⋯ In this study, patients presenting with acute cardiogenic pulmonary oedema and acidosis, were more likely to survive to hospital discharge if treated with CPAP, rather than with bilevel ventilation or with conventional oxygen therapy. There was no relation between in hospital survival and early physiological changes. Survival rates were similar to other studies despite a low rate of endotracheal intubation.
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Cerebral oedema (CO) is the most dreaded complication of diabetic ketoacidosis (DKA) in children. Despite advances in many areas of the management of DKA, the mortality from CO has remained constant for decades. This rare disorder, complicating about 1% of cases of DKA in children, is lethal in 20% to 50% of victims. ⋯ Researchers have suggested that the treatment for DKA may be causally related to the development of CO. Others have disputed this claim, and both camps cite evidence to support their point of view. This article reviews the literature pertinent to the question: Is the treatment of DKA in children responsible for the development of CO?
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A short cut review was carried out to establish whether antibiotics improve recovery in patients with acute exacerbations of COPD. Altogether 200 papers were found using the reported search, of which four presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.
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A short cut review was carried out to establish whether intra-articular corticosteroid injections were effective at reducing pain in patients with acute rheumatoid monoarthritis. Altogether 215 papers were found using the reported search, of which one presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of this best paper are tabulated. A clinical bottom line is stated.
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Case Reports
Lignocaine toxicity; a complication of local anaesthesia administered in the community.
Local anaesthetic agents are among the most commonly used drugs in the emergency department. A case is reported of a complication arising from systemic toxicity after the injection of lignocaine (lidocaine). Emergency practitioners should maintain a high level of vigilance for the symptoms of toxicity after local anaesthetic administration. Particular care should be taken when calculating the maximum safe dose for young children.