Cancer medicine
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Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has demonstrated remarkable efficacy for refractory and relapsed diffuse large B cell lymphoma (R/R DLBCL). However, this therapy failed in nearly 25% patients mainly due to antigen loss. The authors performed a phase Ⅱ trial by coadministration of anti-CD19 and anti-CD20 CAR-T cells treatment for R/R DLBCL and evaluated its efficacy and toxicity. ⋯ Coadministration of anti-CD19 and CD20 CAR-T cells therapy for DLBCL is feasible with manageable toxicity. Cytokine markers are related to toxicity and SUVmax could predict efficacy. This trial was registered at www.clinicaltrials.gov as NCT03207178.
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Mucinous breast carcinoma (MBC) is a relatively rare pathological type of breast cancer. Compared with mastectomy in MBC, the effect and safety of breast-conserving therapy (BCT) remains unclear. Therefore, we investigated the long-term prognosis of BCT and mastectomy in T1-2 stage mucinous breast carcinoma via the Surveillance, Epidemiology, and End Results (SEER) database. ⋯ This large population-based study indicated patients who received BCT had better prognosis than those received mastectomy in T1-2 stage MBC, especially in patients at the age of 50-79 years. The use of radiotherapy showed OS benefit in patients receiving BCT. Breast-conserving therapy might be preferred over mastectomy especially in locoregional treatment of T1-2 stage MBC.