EBioMedicine
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Case Reports
Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.
The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a series of clinical symptoms and severe illnesses, including acute respiratory distress syndrome (ARDS) and fatal organ failure. We report the fundamental pathological investigation in the lungs and other organs of fatal cases for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases. ⋯ Shanghai Guangci Translational Medical Research Development Foundation, Shanghai, China.