United European gastroenterology journal
-
United European Gastroenterol J · Oct 2015
Efficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate response.
Treatment options for patients with opioid-induced constipation (OIC) and inadequate response to laxatives (LIR) are few. ⋯ Naloxegol was efficacious, generally safe and well tolerated in the patients with OIC and LIR, while preserving opioid analgesia. ClinicalTrials.gov identifiers: NCT01309841; NCT01323790.