The Bulletin of Tokyo Medical and Dental University
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Bull. Tokyo Med. Dent. Univ. · Sep 1988
Randomized Controlled Trial Comparative Study Clinical TrialRelationship between subjective pain estimation and somatosensory evoked potentials by electrical tooth stimulation.
The relationship between the amplitude of somatosensory evoked potentials (SEP) and the subjective pain estimation using a visual analogue scale (VAS) was examined in 8 volunteers undergoing randomized electrical tooth stimulation with 3 different intensities. Randomized stimulation was used instead of repetitive stimulation with a fixed intensity in order to minimize the phenomena of habituation and expectancy in recording the SEP and VAS. The VAS scores increased significantly with the stimulus intensity. ⋯ There was a significant correlation between the amplitude of N160-P300 and the VAS scores. These findings indicate that the component between 160 and 300 msec reflects the perceived pain intensity and the psychological evaluation processes such as cognition, meaning, interpretation and appreciation of pain. The method of randomized stimulation can serve as a simple and useful way for the objective or subjective pain estimation.
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Bull. Tokyo Med. Dent. Univ. · Sep 1985
Effect of thiamylal and diazepam on release of myoglobin and creatine phosphokinase by succinylcholine chloride during halothane anesthesia.
The effects of thiamylal and diazepam on the release of myoglobin and creatine phosphokinase following the administration of succinylcholine chloride during halothane anesthesia were studied. Thirty patients receiving halothane anesthesia were divided into three groups. In Group I, 1.5-2 mg/kg of thiamylal were given intravenously as pretreatment before the injection of succinylcholine chloride. ⋯ A significant increase in the serum myoglobin and creatine phosphokinase levels was observed in all groups. However, the values in Group I were significantly lower than those in Groups II and III and a significant difference was not detected between Group II and III. Our results indicate that thiamylal has a considerable inhibitory effect on the release of myoglobin and creatine phosphokinase from the muscle following the administration of succinylcholine chloride.
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Bull. Tokyo Med. Dent. Univ. · Jun 1985
Comparative StudyComparison of hemodynamic effects of morphine, butorphanol, buprenorphine and pentazocine on ICU patients.
Morphine and narcotic agonist-antagonists have been used to assist ICU patients in adapting to mechanical ventilation. In this study, 10 mg of morphine and the equipotent doses of synthetic analgesics, 2 mg of butorphanol, 0.6 mg of buprenorphine or 30 mg of pentazocine were administered intravenously to 29 patients requiring a ventilator. Hemodynamic effects on the heart rate, mean arterial pressure (MAP), cardiac index, stroke index, left ventricular stroke work index, mean pulmonary arterial pressure (MPAP), pulmonary capillary wedge pressure (PCWP) and systemic and pulmonary vascular resistance (PVR) were measured. ⋯ These doses of the four drugs could be given safely even in critically ill patients. The hemodynamic effects of these analgesics showed a similarity between the administration of butorphanol and morphine, and between buprenorphine and pentazocine. This study demonstrates that morphine and butorphanol are preferred to the cases with hypertension, increased pulmonary arterial pressure or wedge pressure and that pentazocine and buprenorphine are more suitable for the cases with hypotension or hypovolemia.
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Bull. Tokyo Med. Dent. Univ. · Mar 1979
An experimental study on the effect of plasma expanders on blood coagulability.
The effect of various plasma expanders on blood coagulation was studied using the thromboelastography (TEG). Solutions of 5, 10, 20, and 50% concentration of each expander (6% low molecular weight hydroxyethyl-starch (6% Hespander), 3% dextran-40, 6% high molecular weight hydroxyethyl-starch (6 HES), and 6% dextran-70) or solvent (lactated Ringer solution and normal saline) in blood were prepared and their coagulability was examined by TEG. ⋯ In the high molecular weight plasma expanders (6 HES and 6% dextran-70), the coagulability increased slightly at low and high concentrations and the coagulability was reduced. As a conclusion, at clinically used concentrations of less than 20% in blood, changes in the TEG of the plasma expanders are minimum and have no clinical significance.
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Bull. Tokyo Med. Dent. Univ. · Mar 1978
Comparative StudyA study on the microbial filtration efficiency of surgical face masks--with special reference to the non-woven fabric mask.
With the experimental apparatus designed and made available by Nicholes, we evaluated the bacterial filtration efficienty (B. F. E.) of the non-woven fabric and cotton cloth masks. ⋯ The B. F. E. of the conventional cotton cloth masks is not only lower but variable over a wide range of 43.1-93.6%.