The Journal of the American Academy of Orthopaedic Surgeons
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Osteogenesis imperfecta is a genetic disorder of type I collagen. Although multiple genotypes and phenotypes are associated with osteogenesis imperfecta, approximately 90% of the mutations are in the COL1A1 and COL1A2 genes. Osteogenesis imperfecta is characterized by bone fragility. ⋯ Use of diphosphonates has been found to decrease the rate of progression of scoliosis in patients with osteogenesis imperfecta. A lateral cervical radiograph is recommended in patients with this condition before age 6 years for surveillance of craniocervical junction abnormalities, such as basilar impression. Intraoperative and anesthetic considerations in patients with osteogenesis imperfecta include challenges related to fracture risk, airway management, pulmonary function, and blood loss.
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J Am Acad Orthop Surg · Feb 2017
ReviewMicrobiology and Antimicrobial Challenges of Prosthetic Joint Infection.
Research that leads to better strategies to diagnose and treat prosthetic joint infection (PJI) is critical because PJI is a devastating complication of total knee arthroplasty. A key to the diagnosis and management of PJI is defining the microbiology of PJI and improving the medical management of PJI utilizing both systemic and local antimicrobial therapy. ⋯ This paper summarizes a presentation given at a recent multidisciplinary research conference entitled "Strategies to improve total knee arthroplasty" sponsored by the Knee Society. It was a part of a session entitled "Periprosthetic Joint Infection."
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J Am Acad Orthop Surg · Feb 2017
The Effect of Cervical Interbody Cage Morphology, Material Composition, and Substrate Density on Cage Subsidence.
Interbody cages used in spinal fusion surgery can subside into the adjacent vertebral bodies after implantation, leading to loss of spinal height, malalignment, and possible radicular symptoms. Several factors may contribute to cage subsidence. ⋯ Ranking of the relative impact of these factors indicated that substrate density had the greatest contribution to the measured subsidence (approximately 1.7 times and approximately 67 times greater than the contributions of cage footprint area and material, respectively). The contribution of cage footprint area to subsidence was found to be 40 times greater than the contribution of cage material to subsidence.