Swiss medical weekly
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Swiss medical weekly · Apr 2004
Editorial CommentInhalation of aerosols by children: an ongoing controversy.
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Swiss medical weekly · Apr 2004
Clinical TrialA complementary combination of delivery device and drug formulation for inhalation therapy in preschool children.
The amount of drug delivered from commercially available inhalation devices which reaches the lungs of preschool children is generally low. We therefore studied the efficiency of lung delivery from an optimised combination of delivery device and drug formulation based on individual patient-related factors. ⋯ Lung deposition of budesonide delivered from the perforated vibrating membrane nebuliser was 36% and 38% and notably higher than from a conventional nebuliser (maximum 8%). The development of complementary combinations of delivery devices and drug formulations to meet the needs of efficient inhalation therapy in preschool children seems to be a good way of improving the efficacy of inhaled therapy in this age group.