Swiss medical weekly
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Swiss medical weekly · Oct 1980
Clinical Trial[Acute myeloblastic leukemia in adults: a cure in sight?].
The author inquires what the chances are in 1980 of curing acute myeloblastic leukemia (AML) in adults. Efforts toward curative treatment are chiefly concentrated in three places: the basic science laboratories, the clinical laboratories, and the bedside. ⋯ A small number of patients achieve many years of remission and are perhaps even cured, but it is impossible to predict what patients can expect longterm remissions. Painstaking investigation of this group of patients may provide the clue to curative treatment for AML as early as the present decade.
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Swiss medical weekly · Sep 1980
[Dermatological complications in immunosuppressed patients after kidney transplantation].
205 recipients of renal allotransplants were evaluated either by clinical examination (n = 91) or by study of records (n = 114). More than 75% of the patients studied had dermatologic problems in the late post transplant phase, 25% having 2 or more such conditions. ⋯ Infections included warts (29%), herpes simplex (13%), herpes zoster (7%), and candidiasis (29%). 9 patients (4.4%) had skin carcinomas which were diagnosed on average 6.2 years after transplantation. The frequency of skin lesions during immunosuppressive therapy after renal allotransplantation requires regular skin inspections and information to patients on the potential risks.
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Swiss medical weekly · May 1980
Case Reports[Pancreatic cancer associated with pancreatitis and pseudocysts].
A discussion is presented of the diagnostic problems encountered in 27 of 153 consecutive cases of pancreatic cancer, all of which were initially misinterpreted as acute (relapsing) or chronic pancreatitis or pancreatic pseudocysts.
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The effect of lysolecithin on gastric mucosa in rats has been investigated using a new operative model. Ten rats underwent sham-laparotomy. In 4 other groups, each of 10 animals, the rats underwent pyloro-jejunostomy and Roux-en-Y anastomosis. 9 of 10 rats operated upon in this way, and given a solution of lysolecithin to drink before administration of restraint stress, produced stress ulcers. ⋯ Lysolecithin not combined with stress had no noteworthy deleterious effect on gastric mucosa either in sham-operated rats or in those with our operation model. Thus, lysolecithin combined with stress in our model performed an important function in the pathogenesis of stress lesions. Lysolecithin is produced in considerable quantities during fat metabolism in the intestine, and may be regurgitated together with duodenal contents into the stomach.