Zhongguo yao li xue bao = Acta pharmacologica Sinica
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Zhongguo Yao Li Xue Bao · May 1994
Protective effect of dipfluzine on experimental brain edema in rats.
The effects of dipfluzine (1-diphenylmethyl-4-(3-(4-fluorobenzoyl))-piperazine, Dip), a new calcium antagonist developed in China, on experimental brain edema in female Wistar rats with bilateral carotid artery ligation were compared with those of cinnarizine (Cin). Dip 25-100 mg.kg-1 i.p. protected the rats against the characteristic signs of global cerebral ischemia that correlate well with the development of brain edema. ⋯ Dip 50 mg.kg-1 i.p. attenuated the reduction in cerebral blood flow (CBF) and the infarct size after occlusion, but did not alter CBF before ischemia. These findings suggested that Dip may be potentially useful to treat ischemic brain edema in part by preserving CBF in the ischemic zone.