Zhongguo yao li xue bao = Acta pharmacologica Sinica
-
Zhongguo Yao Li Xue Bao · Aug 1999
dl-3-n-butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats.
To study the protective effect of dl-3-n-butylphthalide (NBP) on blood-brain barrier (BBB) damage induced by reperfusion following focal cerebral ischemia. ⋯ NBP has protective effect on BBB damage induced by reperfusion after MCAO.
-
Zhongguo Yao Li Xue Bao · May 1998
Cytokine and nitric oxide production by rat microglia stimulated with lipopolysaccharides in vitro.
To study the characterization of interleukin (IL)-1, IL-2, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) production in microglia stimulated with lipopolysaccharides (LPS). ⋯ Rat microglia stimulated with LPS in vitro produced proinflammatory cytokines and NO.
-
Zhongguo Yao Li Xue Bao · Sep 1994
[Effects of furyl-dihydropyridine I on coronary collateral circulation in myocardial infarction of dogs].
Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 micrograms.kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28.9 +/- 1.3% to 15.3 +/- 1.2% (P < 0.01, n = 6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia.
-
Zhongguo Yao Li Xue Bao · May 1994
Protective effect of dipfluzine on experimental brain edema in rats.
The effects of dipfluzine (1-diphenylmethyl-4-(3-(4-fluorobenzoyl))-piperazine, Dip), a new calcium antagonist developed in China, on experimental brain edema in female Wistar rats with bilateral carotid artery ligation were compared with those of cinnarizine (Cin). Dip 25-100 mg.kg-1 i.p. protected the rats against the characteristic signs of global cerebral ischemia that correlate well with the development of brain edema. ⋯ Dip 50 mg.kg-1 i.p. attenuated the reduction in cerebral blood flow (CBF) and the infarct size after occlusion, but did not alter CBF before ischemia. These findings suggested that Dip may be potentially useful to treat ischemic brain edema in part by preserving CBF in the ischemic zone.