American journal of Alzheimer's disease and other dementias
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Am J Alzheimers Dis Other Demen · Nov 2012
Review Case ReportsAgitation and psychosis associated with dementia with lewy bodies exacerbated by modafinil use.
Dementia with Lewy bodies (DLB) is commonly associated with excessive daytime somnolence (EDS). Modafinil is a wakefulness-promoting agent that is considered to have limited interaction with the dopaminergic system. ⋯ In both cases, psychotic symptoms emerged concomitantly with modafinil administration and remitted following its discontinuation. Although definitive data regarding the benefits and adverse effects of modafinil for the treatment of EDS in DLB await controlled prospective randomized studies, our observations warrant caution regarding its use in this context.