American journal of Alzheimer's disease and other dementias
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Am J Alzheimers Dis Other Demen · Mar 2013
ReviewThe possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention.
Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer's disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. ⋯ However, clinical trials using antioxidants, including vitamin C, in patients with AD yielded equivocal results. The current article discusses the relevance of vitamin C in the cellular and molecular pathogenesis of AD and explores its therapeutic potential against this neurodegenerative disorder.