American journal of Alzheimer's disease and other dementias
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Am J Alzheimers Dis Other Demen · Jan 2020
A Reliable Tool for Assessing MCI and Dementia: Validation Study of DemTect for Turkish Population.
Mild cognitive impairment (MCI) and dementia prevalence are expected to increase with aging. The DemTect is a very quick and easy tool to administer and recognize the early stages of dementia and MCI. In this study we aimed to evaluate the reliability and validity of a Turkish version of the DemTect and define cut off values for different age and educational levels. One of our aims is also to compare the sensitivity and specifity of the DemTect to other common screening tools. ⋯ The DemTect is a very reliable tool to assess Turkish patients with MCI and dementia.
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Am J Alzheimers Dis Other Demen · Jan 2020
Meta AnalysisCirculating MicroRNAs as Diagnostic Biomarkers of Clinical Cognitive Impairment: A Meta-Analysis.
Minimally invasive diagnostic biomarkers of neurodegenerative diseases such as Alzheimer's disease (AD) facilitate patient selection and cognitive progressive decline monitoring. However, the diagnostic value of circulating microRNAs (miRNAs) for early cognitive impairment and progression to dementia is currently under debate. Thus, this study aimed to assess the diagnostic performance of circulating, cerebrospinal fluid (CSF) and exosomal miRNAs in the detection of clinical cognitive impairment in mild cognitive impairment (MCI), AD, and MCI-AD. ⋯ Our study found that miRNAs have certain diagnostic value for cognitive impairment, with high sensitivity and specificity, especially in diagnostics with multiple miRNAs and serum-based miRNA assays.
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Am J Alzheimers Dis Other Demen · Jan 2020
Loneliness and Burden Perceived by Family Caregivers of Patients With Alzheimer Disease.
The present study aimed at investigating loneliness and burden experienced by family members caring for relatives diagnosed with Alzheimer disease. ⋯ Loneliness reported by caregivers of relatives diagnosed with dementia is significantly modulated by caregiver (but not patient) characteristics. Notably, both uni- and multidimensional loneliness scales seem to be sensitive diagnostic tools.