Arquivos de neuro-psiquiatria
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Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of clinical trials research is the double-blind, placebo-controlled, randomized clinical study. ⋯ Placebo and nocebo effects have been considered in neurological diseases such as depression, pain, headache, multiple sclerosis, epilepsy. As placebo and nocebo effects are also present in clinical practice, the purpose of this review is to draw attention to their influence on neurological practice, calling attention to the development of measures that can minimize them.
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To present a seven-cases serie of Mowat-Wilson syndrome (MWS). ⋯ Physicians who care for patients with mental retardation and epilepsy should be aware of SMW.