Internal medicine journal
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Internal medicine journal · Nov 2001
Practice Guideline GuidelineFibre-optic bronchoscopy in adults: a position paper of The Thoracic Society of Australia and New Zealand.
Fibre-optic bronchoscopy in adults is a common procedure in clinical respiratory practice. Under controlled conditions it is safe, resulting in relatively few significant adverse events. ⋯ Where no evidence has been found, the guidelines reflect the opinions of the authors. Specific recommendations are made regarding sedation and anaesthesia, the cleaning of bronchoscopes and the training of bronchoscopists.
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Internal medicine journal · Nov 2001
Comment Letter Case ReportsSpontaneous coronary dissection following exertion: support for a hypothesis.
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Internal medicine journal · Nov 2001
ReviewIncreasing relevance of pharmacogenetics of drug metabolism in clinical practice.
Much of the individual variation in drug response is due to genetic drug metabolic polymorphisms. Clinically relevant examples include acetylator status; cytochrome P450 2D6, 2C9 and 2C19 polymorphisms; and thiopurine methyltransferase deficiency. It is important to be aware of which drugs are subject to pharmacogenetic variability. In the future, population-based pharmacogenetic testing will allow more individualized drug treatment and will avoid the current empiricism.
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Internal medicine journal · Nov 2001
Survival on long-term oxygen therapy in chronic airflow limitation: from evidence to outcomes in the routine clinical setting.
Two previous randomized controlled trials (RCT) demonstrated that the administration of long-term oxygen therapy (LTOT) improved survival in selected patients with hypoxic chronic obstructive pulmonary disease (COPD) or chronic airflow limitation (CAL). ⋯ In routine practice, survival of unselected CAL patients with multiple comorbidities is less than that reported in the original RCT.