Internal medicine journal
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Internal medicine journal · Oct 2015
Multicenter StudyIpilimumab-induced hypophysitis in melanoma patients: an Australian case series.
Ipilimumab (Yervoy; Bristol-Myers Squibb) is a novel fully humanised monoclonal antibody that blocks cytotoxic T-lymphocyte antigen 4, an immune checkpoint molecule, to augment anti-tumour T-cell responses. It is associated with significant immune-related side-effects including hypophysitis. ⋯ There is significant morbidity associated with development of IH. We suggest guidelines to assist with early recognition and therapeutic intervention.
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Internal medicine journal · Oct 2015
Case ReportsDisseminated Mycobacterium haemophilum skeletal disease in a patient with interferon-gamma deficiency.
Disseminated non-tuberculous mycobacterial (NTM) infection is rare in immunocompetent adults. Anti-interferon-gamma (IFN-γ) autoantibodies have recently been associated with NTM infections, particularly in patients of Asian ethnicity. ⋯ He responded to a combination of anti-mycobacterial antibiotics without requirement for immunomodulator therapy. Testing for acquired IFN-γ deficiency due to IFN-γ autoantibodies should be considered when standard tests for immunodeficiency are negative in patients with unusual or severe opportunistic infections, including NTM.
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Internal medicine journal · Oct 2015
Letter Case ReportsTwo cases of spondylodiscitis caused by Parvimonas micra.