IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
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IEEE Trans Neural Syst Rehabil Eng · Jul 2015
A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator.
Controlled, wireless neuromodulation using miniature implantable devices is a long-sought goal in neuroscience. It will allow many studies and treatments that are otherwise impractical. Recent studies demonstrate advances in neuromodulation through optogenetics, but test animals are typically tethered, severely limiting experimental possibilities. ⋯ We demonstrate its use in a behavioral experiment targeting a deep brain structure in freely behaving mice. To allow its rapid and widespread adoption, we developed this stimulator using commercially available components. The modular and accessible optogenetic stimulator presented advances the wireless toolset available for freely behaving animal experiments.