Best practice & research. Clinical rheumatology
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Best Pract Res Clin Rheumatol · Dec 2001
ReviewNeuroendocrine mechanisms in fibromyalgia-chronic fatigue.
Fibromyalgia and chronic fatigue syndrome are poorly understood disorders that share similar demographic and clinical characteristics. Because of the clinical similarities between both disorders it was suggested that they share a common pathophysiological mechanism, namely, central nervous system dysfunction. ⋯ The possible contribution of the central nervous system dysfunction to the development and symptomatology of these conditions is discussed. The chapter concludes by reviewing the effect of current treatments and emerging therapeutic modalities in fibromyalgia and chronic fatigue syndrome.