Clinical biochemistry
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Clinical biochemistry · Feb 2002
Comparative StudyUbiquinone-10 content in lymphocytes of phenylketonuric patients.
To investigate the ubiquinone-10 content in lymphocytes from phenylketonuric patients. ⋯ Ubiquinone-10 concentrations are decreased in lymphocytes from phenylketonuric patients. This deficiency is associated with high plasma phenylalanine concentrations.
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The anion gap has proved a valuable tool in the diagnosis of various forms of acid-base disorders, although the importance of slight rises in the anion gap remains unclear. The concept of the anion gap is often misunderstood and misapplied. The relationship between gammaglobulins and the serum anion gap has not received much attention except for reports of a narrowing of the gap associated with certain monoclonal immunoglobulin G gammopathies. We present patients with polyclonal gammopathy, the magnitude of which correlated strongly and negatively with the anion gap. ⋯ Our results show a negative correlation between serum anion gap and gammaglobulins concentration.