Clinical biochemistry
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Clinical biochemistry · Jan 2012
Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity.
The matrix protein hyaluronic acid (HA, hyaluronan) has possibly additional immune-regulatory functions in inflammation. We aimed at evaluating serum HA concentrations in critically ill patients. ⋯ Measurement of serum HA may supplement the assessment of disease severity in ICU patients. Our data suggest that HA might have implications in the pathogenesis of critical illness and sepsis.