Clinical biochemistry
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Clinical biochemistry · Nov 2013
Diagnostic performance of four point of care cardiac troponin I assays to rule in and rule out acute myocardial infarction.
This study evaluated the diagnostic performance of four point-of-care (POC) cardiac troponin I (cTnI) assays compared to a central laboratory cTnI assay for detecting myocardial injury and diagnosing acute myocardial infarction (AMI). ⋯ cTnI is a sensitive biomarker for detection of myocardial injury. The analytical variability that exists between POC cTnI assays demonstrates substantial diagnostic differences for ruling in and ruling out MI in patients presenting with symptoms suggestive of ACS.
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Clinical biochemistry · Nov 2013
Association of FAM13A polymorphisms with COPD and COPD-related phenotypes in Han Chinese.
Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and FAM13A polymorphisms in non-Asian populations. The aim of this study was to investigate whether FAM13A polymorphisms would be associated with COPD susceptibility and COPD-related phenotypes in a Chinese Han population. ⋯ The current study suggests that the FAM13A locus might be a contributor to COPD susceptibility in Chinese Han population.