Nature reviews. Cancer
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Nature reviews. Cancer · Sep 2002
Review Historical ArticleHow acute promyelocytic leukaemia revived arsenic.
Despite its many therapeutic qualities, arsenic trioxide has been more commonly remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic trioxide to treat acute promyelocytic leukaemia has radically changed this view, providing new insights into the pathogenesis of this malignancy and raising hopes that arsenicals might be useful in treating other cancers.